Bromazolam

Bromazolam

Professional Triazolobenzodiazepine Reference Standards for Global Research & Analytical Applications

Bromazolam (8-bromo-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, CAS 71368-80-4) is a synthetic benzodiazepine derivative utilised as an analytical reference standard in forensic toxicology, NPS monitoring programmes, and GABA receptor pharmacology research. As a structurally novel triazolobenzodiazepine featuring a characteristic bromine substitution, this compound serves critical functions in laboratories investigating benzodiazepine structure-activity relationships, novel psychoactive substance identification, and clinical toxicology across Europe, North America, Asia-Pacific, and international professional markets.

At realchemsupply.com, we supply high-purity Bromazolam analytical standards manufactured to stringent industrial specifications for qualified organisations worldwide. Our international B2B chemical supply infrastructure supports forensic laboratories, universities, research institutions, analytical facilities, and industrial manufacturers requiring consistent, documented reference materials for benzodiazepine differentiation and research applications.

What Are Bromazolam Products?

Chemical Classification and Overview

Bromazolam belongs to the triazolobenzodiazepine chemical class, characterised by a fused triazole ring incorporated into the classic 1,4-benzodiazepine scaffold. This structural modification distinguishes it from conventional 1,4-benzodiazepines and creates distinct physicochemical and pharmacological properties. The systematic IUPAC designation reflects the complex polycyclic structure with bromine substitution at the 8-position.

Molecular Formula: C₁₇H₁₃BrN₄
Molecular Weight: 353.22 g/mol
CAS Registry Number: 71368-80-4
Chemical Class: Triazolobenzodiazepine; Benzodiazepine derivative

The bromine substitution at the 8-position, combined with the triazole ring fusion, creates a compound with enhanced potency and distinct metabolic pathways compared to earlier benzodiazepine generations. This structural configuration differentiates Bromazolam from alprazolam (chlorine-substituted), flubromazolam (fluorine-substituted), and other halogenated analogues in both chemical properties and analytical behaviour.

General Characteristics and Industrial Relevance

Triazolobenzodiazepine reference standards like Bromazolam serve essential functions within professional chemical analysis and research workflows:

  • Forensic Toxicology: Identification and quantification in biological matrices for post-mortem investigations, clinical toxicology, impaired driving assessments, and drug-facilitated crime analysis
  • NPS Surveillance: Early warning system participation and seized material characterisation for border control, law enforcement, and regulatory monitoring programmes tracking novel benzodiazepine emergence
  • GABA Receptor Research: Benzodiazepine binding site investigations, structure-activity relationship analysis, and comparative pharmacology studies
  • Metabolic Pathway Studies: Characterisation of phase I and phase II metabolic transformations, including cytochrome P450 involvement and active metabolite formation
  • Analytical Method Development: Validation of chromatographic and spectroscopic techniques for emerging benzodiazepine differentiation from classical and novel analogues

Professional organisations source these materials through qualified B2B chemical suppliers to ensure batch consistency, documented purity, and regulatory compliance for forensic defensibility and research reproducibility.

Procurement Considerations

When sourcing Bromazolam reference standards, professional buyers evaluate:

  • Specification Documentation: Comprehensive analytical data including HPLC purity, NMR spectroscopic confirmation, high-resolution mass spectrometry, and residual solvent analysis
  • Structural Verification: Capability to distinguish from alprazolam, flubromazolam, clonazolam, and other halogenated triazolobenzodiazepines
  • Batch Consistency: Reproducible quality across multiple orders for longitudinal forensic studies and research programmes
  • Storage Stability: Light-sensitive and potentially hygroscopic compound requiring appropriate packaging and handling protocols
  • Regulatory Documentation: Compliance with international controlled substance scheduling, analogue regulations, and benzodiazepine-specific controls

Real Chem Supply provides Certificates of Analysis, Safety Data Sheets, and stability data suitable for laboratory accreditation standards including ISO/IEC 17025 and forensic quality management systems.

Types of Products Available

The Bromazolam category encompasses various product formats suited to different professional applications, analytical requirements, and handling protocols.

Reference Standard Formats

Solid Reference Standards:

  • Crystalline powders for precise weighing and solution preparation
  • Free-base or salt forms depending on stability and solubility requirements
  • High-purity grades for quantitative analytical and forensic applications
  • Materials suitable for HRMS, NMR, and chromatographic method development

Prepared Solutions:

  • Pre-weighed analytical standards in appropriate solvents (methanol, acetonitrile, DMSO)
  • Concentration-verified solutions for direct instrumental calibration
  • Multi-analyte mixtures including related benzodiazepines for comprehensive screening panels
  • Deuterated internal standard preparations for quantitative LC-MS/MS applications

Analytical Materials:

  • HRMS-grade standards for accurate mass confirmation and isotopic pattern verification (including bromine isotope signature)
  • NMR spectroscopy standards for structural confirmation and impurity profiling
  • Chromatographic standards for retention time library development and method validation

Product Form Considerations

Laboratory selection depends upon:

  • Application Requirements: Qualitative screening versus quantitative confirmation analysis; forensic casework versus receptor binding studies
  • Stability Profiles: Solid forms generally offer enhanced stability; solutions require refrigerated storage and light protection
  • Handling Efficiency: Pre-prepared solutions reduce preparation variability in high-throughput forensic toxicology laboratories
  • Matrix Compatibility: Solvent selection appropriate for intended analytical platform (LC-MS/MS, GC-MS, HPLC-DAD)

Availability of specific forms varies by product batch, manufacturing specifications, and stability considerations. Professional buyers should confirm current configurations with realchemsupply.com prior to procurement.

Industrial and Professional Applications

Chemical Manufacturing and Process Development

Industrial chemists utilise Bromazolam reference standards for:

  • Impurity Profiling: Identification of synthetic by-products, regioisomers, and related benzodiazepines in chemical synthesis monitoring
  • Quality Control: Verification of product identity and assessment of cross-contamination in multi-product facilities
  • Method Validation: Development of analytical procedures capable of distinguishing Bromazolam from alprazolam, flubromazolam, and other triazolobenzodiazepines

University and Research Institution Applications

Academic research programmes incorporate Bromazolam into:

  • Pharmacological Studies: GABA-A receptor binding affinity, subtype selectivity, and functional activity assays
  • Metabolism Research: In vitro metabolic stability, CYP450 isoform identification (particularly CYP3A4), and metabolite characterisation
  • Forensic Chemistry Education: Training in benzodiazepine identification, differentiation from classical benzodiazepines, and analytical technique development
  • Computational Chemistry: Molecular modelling of halogen substitution effects on receptor binding and metabolic stability

Analytical Laboratory Workflows

Commercial and government testing laboratories employ Bromazolam standards for:

  • Confirmation Testing: Definitive identification following preliminary screening by immunoassay or LC-MS/MS panels
  • Quantitative Analysis: Calibration curve preparation for concentration determination in blood, urine, and post-mortem tissues
  • Benzodiazepine Differentiation: Chromatographic and mass spectrometric separation from diazepam, alprazolam, and novel NPS benzodiazepines
  • Proficiency Testing: External quality assessment scheme participation for forensic toxicology laboratories

Forensic and NPS Monitoring

Law enforcement and regulatory laboratories utilise Bromazolam for:

  • Seized Material Identification: Confirmation of substance identity in border seizures, criminal investigations, and postal interdictions
  • NPS Early Warning: Detection of emerging benzodiazepine variants in drug monitoring and surveillance programmes
  • Toxicological Casework: Clinical and post-mortem investigations involving novel benzodiazepine exposure, often in combination with opioids or other CNS depressants

All applications are conducted within appropriate professional frameworks, with strict adherence to workplace safety protocols, institutional biosafety guidelines, controlled substance regulations, and applicable ethical review requirements.

Quality Standards and Procurement Considerations

Product Quality Evaluation

Professional procurement teams assess Bromazolam suppliers based on rigorous quality indicators:

Analytical Documentation:

  • High-performance liquid chromatography (HPLC) purity determination with UV (254 nm) or MS detection
  • Proton (¹H) and carbon-13 (¹³C) NMR spectroscopic confirmation
  • High-resolution mass spectrometry (HRMS) with accurate mass measurement and bromine isotope pattern verification
  • Fourier-transform infrared (FT-IR) spectral verification
  • Thermal analysis (DSC, TGA) for solid form characterisation
  • Residual solvent analysis by GC-HS

Structural Verification:

  • Chromatographic retention time differentiation from alprazolam, flubromazolam, and related triazolobenzodiazepines
  • Mass spectrometric fragmentation pattern distinctiveness (bromine isotope signature diagnostic)
  • UV-Vis spectroscopic confirmation of benzodiazepine chromophore

Supply Chain Reliability

International chemical procurement requires evaluation of:

  • Inventory Management: Consistent availability for recurring forensic casework and research requirements
  • Lead Time Transparency: Realistic production and shipping schedules
  • Communication Standards: Technical support for analytical, regulatory, and handling enquiries
  • Order Fulfilment: Accurate picking, light-protective packaging, and complete documentation

Documentation and Compliance

Professional buyers require comprehensive paperwork:

  • Safety Data Sheets (SDS): Hazard classification (CNS depressant, sedative), handling precautions, and emergency procedures
  • Certificates of Analysis (CoA): Batch-specific analytical results with specification compliance statements
  • Regulatory Declarations: Controlled substance status, benzodiazepine scheduling information, and export control classification
  • Chain of Custody: Documentation supporting forensic laboratory accreditation and legal defensibility

International Logistics Considerations

Cross-border procurement of benzodiazepine reference standards involves:

  • Customs Classification: Accurate HS code assignment for heterocyclic compounds and psychoactive substances
  • Transport Regulations: Compliance with dangerous goods requirements for sedative/hypnotic substances
  • Import Licensing: Verification of Schedule IV/Class C research permits and end-use certificates
  • Documentation Accuracy: Commercial invoices, packing lists, and analytical certificates for customs clearance

Buyers should verify applicable import, export, customs, and controlled substance regulations in their jurisdiction before ordering, as benzodiazepine analogues are strictly regulated in most international markets.

Product Forms

Bromazolam may be available in various physical forms depending on the specific product grade, salt form, and intended application:

Solid Forms

Crystalline Materials:

  • Well-defined crystal morphology suitable for X-ray crystallographic analysis
  • High chemical purity with characteristic solid-state stability properties
  • Defined melting point for identity confirmation

Amorphous Powders:

  • Homogeneous particle size distribution for accurate gravimetric preparation
  • Enhanced handling characteristics for laboratory preparation
  • Professional packaging with desiccant and light protection

Salt Forms:

  • Hydrochloride or other salt forms offering enhanced stability and solubility
  • Defined stoichiometry for quantitative analytical applications

Liquid and Solution Forms

Prepared Analytical Solutions:

  • Pre-dissolved in HPLC-grade or LC-MS-grade solvents
  • Concentration-verified by quantitative analytical techniques
  • Amber glass packaging with appropriate storage conditions

Availability of specific forms depends on product specifications, batch characteristics, and stability profiles. Professional buyers should confirm current configurations with realchemsupply.com.

Packaging Options

Real Chem Supply provides professional packaging appropriate for light-sensitive benzodiazepine compounds:

Standard Laboratory Quantities

  • 10 mg – 100 mg: Amber borosilicate glass vials with inert atmosphere and desiccant
  • 250 mg – 500 mg: Light-protective containers with tamper-evident closures
  • 1 g: Bulk laboratory packaging with comprehensive documentation

Commercial and Bulk Options

  • 5 g and above: Wholesale quantities for industrial users and distributors (where available)
  • Custom packaging: Specialised containers for specific institutional requirements
  • Multi-site shipments: Consolidated packaging for distributed laboratory networks

Packaging Features

Professional chemical packaging includes:

  • Light Protection: Amber glass or aluminium-foil wrapped containers
  • Inert Atmosphere: Nitrogen or argon flushing for oxygen-sensitive materials
  • Moisture Control: Molecular sieve desiccants and moisture-barrier packaging
  • Tamper Evidence: Sealed closures with integrity indicators
  • GHS Labelling: Globally Harmonized System hazard communication for sedative substances

Packaging specifications vary according to product properties, quantity, shipping requirements, and destination regulations. Bulk quantities and customised packaging solutions may be available upon request, subject to product availability and commercial requirements.

Storage and Handling

General Professional Storage Guidance

Appropriate storage of Bromazolam reference standards maintains analytical integrity:

Environmental Conditions:

  • Cool, dry storage environment (typically 2–8°C for extended stability)
  • Absolute protection from light and UV exposure
  • Low humidity environment with active desiccant
  • Inert atmosphere maintenance where provided

Container Management:

  • Maintain sealed closures when not in use
  • Minimise headspace exposure during sampling
  • Use amber vessels for solution storage
  • Monitor for physical changes indicating degradation

Workplace Safety Protocols

Professional handling requires:

  • Personal Protective Equipment: Laboratory coats, safety glasses, and appropriate gloves
  • Ventilation: Fume hood usage for powder handling and solution preparation
  • Spill Response: Absorbent materials and neutralising agents per SDS recommendations
  • Waste Management: Institutional hazardous waste protocols for controlled substances
  • Security: Controlled substance storage requirements (locked safes, access logs)

Documentation and Traceability

Laboratory best practices include:

  • Maintaining batch records and CoA documentation
  • Recording opening dates, storage conditions, and retest intervals
  • Implementing first-in-first-out inventory rotation
  • Monitoring for physical changes indicating degradation

Professional users should consult the applicable Safety Data Sheet and product-specific handling requirements. Storage and handling protocols must comply with local controlled substance regulations, workplace chemical safety requirements, and institutional biosafety guidelines.

Why Choose realchemsupply.com?

Professional Chemical Sourcing

Real Chem Supply operates as an international B2B chemical supplier serving professional organisations with:

  • Industrial-grade chemical supply: Materials manufactured to specifications suitable for forensic and analytical applications
  • Reference standard quality: Comprehensive analytical documentation supporting laboratory accreditation
  • Batch consistency: Rigorous quality control ensuring reproducible specifications

International B2B Service

Our global chemical supply network serves professional customers across:

  • Europe: Germany, France, Netherlands, Belgium, Spain, Italy, Switzerland, Austria, Sweden, Norway, Denmark, Finland, Poland, Ireland, Portugal, and United Kingdom
  • North America: United States, Canada, and Mexico
  • Asia-Pacific: Japan, South Korea, Singapore, Australia, New Zealand, and India
  • Middle East: United Arab Emirates, Saudi Arabia, and Israel
  • Latin America: Brazil, Argentina, and Chile
  • Africa: South Africa, Nigeria, and Kenya

Commercial Procurement Support

We provide professional services including:

  • Bulk availability: Wholesale quantities for industrial users and research institutions
  • Responsive communication: Dedicated support for quotations and technical enquiries
  • Secure packaging: Professional containers meeting international shipping requirements
  • Documentation completeness: CoA, SDS, and regulatory paperwork for import compliance

Long-Term Supply Relationships

Real Chem Supply prioritises ongoing partnerships:

  • Inventory planning: Support for recurring supply requirements
  • Consistent quality: Reliable sourcing maintaining specification continuity
  • Technical consultation: Guidance on benzodiazepine analytics and differentiation

Industries We Supply

Real Chem Supply serves diverse professional sectors:

Research and Academic Institutions

  • Universities: Chemistry, pharmacology, toxicology, and forensic science departments
  • Research institutes: Public and private organisations conducting NPS monitoring and GABA receptor research
  • Technical universities: Vocational training for analytical chemistry and forensic laboratory technicians

Analytical and Testing Laboratories

  • Forensic laboratories: Police, government, and private toxicology facilities in Berlin, Paris, Amsterdam, London, New York, Los Angeles, and international centres
  • Clinical laboratories: Hospital and healthcare system toxicology services
  • Commercial testing: Environmental, pharmaceutical, and industrial analysis services

Pharmaceutical and Industrial Research

  • Pharmaceutical manufacturers: Impurity profiling, metabolite identification, and method development
  • Chemical research: Structure-activity relationship studies and synthetic route development
  • Industrial research: Product development and materials science applications

Distribution and Wholesale

  • Chemical distributors: Regional and international supply companies serving local markets
  • Laboratory suppliers: Scientific equipment and consumables distributors
  • Reference material specialists: Niche market procurement services for forensic and research institutions

All customers are qualified professional organisations with appropriate institutional credentials, controlled substance licences, and regulatory authorisations for benzodiazepine procurement.

Global Chemical Supply

International B2B Chemical Procurement

Real Chem Supply facilitates professional chemical procurement across international borders, serving scientific and forensic markets while maintaining compliance with strict regional regulatory frameworks for controlled substance analogues.

Regional Market Coverage

European Markets:
Supplying accredited laboratories across Germany (Berlin, Frankfurt, Munich), France (Paris, Lyon), Netherlands (Amsterdam, Rotterdam), Belgium (Brussels, Antwerp), Spain (Madrid, Barcelona), Italy (Milan, Rome), Switzerland (Zurich, Geneva), Austria (Vienna), Scandinavia (Stockholm, Copenhagen, Oslo), and United Kingdom (London, Manchester).

North American Operations:
Serving licensed research institutions and forensic laboratories throughout the United States (New York, Los Angeles, Chicago, Boston, Miami), Canada (Toronto, Vancouver, Montreal), and Mexico (Mexico City).

Asia-Pacific Distribution:
Supporting scientific organisations in Japan (Tokyo, Osaka), South Korea (Seoul), Singapore, Australia (Sydney, Melbourne, Brisbane), New Zealand (Auckland), and India (Mumbai, Delhi, Bangalore).

Other Markets:
Supplying qualified professional customers in Brazil (São Paulo), UAE (Dubai, Abu Dhabi), Saudi Arabia (Riyadh), South Africa (Johannesburg, Cape Town), and other jurisdictions with appropriate regulatory frameworks.

International Logistics and Compliance

Cross-border supply of benzodiazepine reference standards requires:

  • Import and export regulations: Strict compliance with Schedule IV/Class C controlled substance regulations, dual-use controls, and end-use certification
  • Customs documentation: Accurate classification, valuation, and analytical certification for psychoactive substances
  • Transport safety: Adherence to dangerous goods regulations with appropriate security measures
  • Regulatory verification: Confirmation of recipient DEA/HC-equivalent licensing and research authorisation

International buyers must verify applicable regulations in their jurisdiction before ordering. Real Chem Supply provides documentation support within legal frameworks, but compliance responsibility rests with the purchaser.

Why International Industrial Buyers Choose realchemsupply.com

Reliable Sourcing and Supply Chain Integrity

Professional procurement managers value:

  • Regulatory compliance understanding: Knowledge of complex benzodiazepine analogue regulations
  • Documentation quality: Comprehensive analytical and regulatory paperwork supporting import clearance
  • Supply chain security: Appropriate handling and shipping protocols for controlled substances

Professional B2B Procurement Experience

Our commercial operations support:

  • Quotation responsiveness: Timely provision of pricing, availability, and lead time information
  • Regulatory guidance: Support for import licensing, end-use certificates, and customs documentation
  • Order processing: Efficient handling with appropriate security and confidentiality measures

Product Availability and Inventory

We maintain strategic inventory for:

  • Standard requirements: Common benzodiazepine reference standards for forensic and research applications
  • Custom sourcing: Specialised materials available upon request with appropriate lead times

Professional Logistics and Packaging

International shipments receive specialised handling:

  • Export packaging: Light-protective, secure packaging meeting IATA requirements
  • Documentation accuracy: Complete commercial invoices, analytical certificates, and regulatory declarations
  • Chain of custody: Appropriate documentation for controlled substance shipments

Long-Term Supplier Relationships

Real Chem Supply emphasises partnership development:

  • Account management: Dedicated support for recurring customers with appropriate confidentiality
  • Technical consultation: Guidance on benzodiazepine analytics, differentiation, and regulatory developments
  • Market intelligence: Updates on scheduling changes and emerging benzodiazepine variants

Frequently Asked Questions — Global B2B Chemical Procurement

What are Bromazolam products?

Bromazolam is a triazolobenzodiazepine compound used as an analytical reference standard in forensic toxicology, NPS monitoring, and GABA receptor research. The bromine substitution and fused triazole ring distinguish it from classical benzodiazepines and create distinct analytical signatures.

Who purchases Bromazolam products?

Professional customers include forensic toxicology laboratories, clinical laboratories, NPS early warning programmes, university research departments, pharmaceutical manufacturers, and industrial research organisations. All buyers must possess appropriate institutional credentials, controlled substance research licences, and regulatory authorisations.

Are bulk quantities available?

Bulk quantities may be available depending on product specifications, regulatory considerations, current inventory, and commercial requirements. Availability is subject to controlled substance regulations in the destination jurisdiction. Contact realchemsupply.com to discuss specific requirements.

Which industries use these chemicals?

Primary industries include forensic science and toxicology, clinical laboratory medicine, academic research and education, pharmaceutical development and impurity profiling, NPS surveillance programmes, and scientific instrumentation calibration. Applications are strictly professional, forensic, clinical, and research-oriented.

Can laboratories order wholesale quantities?

Qualified laboratories and research institutions with appropriate controlled substance licensing may request commercial pricing for larger volume orders. Terms depend on regulatory compliance, order quantity, shipping destination, and institutional credentials. Contact realchemsupply.com for customised quotations.

What packaging sizes are available?

Standard packaging ranges from 10 mg to 1 g quantities in light-protective amber glass containers with inert atmosphere sealing. Larger quantities may be available subject to regulatory approval. Packaging includes desiccant, tamper-evident closures, and GHS-compliant labelling.

How should Bromazolam products be stored?

Professional storage requires cold conditions (typically 2–8°C), absolute protection from light, low humidity with desiccant, and inert atmosphere where provided. Benzodiazepines are sensitive to photodegradation. Storage protocols must comply with controlled substance security requirements and local workplace safety regulations.

Does realchemsupply.com supply international customers?

Yes, Real Chem Supply operates as an international B2B chemical supplier serving professional organisations across Europe, North America, Asia-Pacific, Middle East, Africa, and Latin America where appropriate regulatory frameworks permit benzodiazepine reference standard importation. All shipments require verification of recipient licensing and compliance with controlled substance regulations.

Can businesses request customised supply solutions?

Customised packaging, concentrations, and procurement arrangements may be available depending on commercial requirements, regulatory compliance, and product specifications. Contact our commercial team to discuss specific institutional needs within applicable legal frameworks.

Why choose realchemsupply.com as a chemical supplier?

Professional buyers choose Real Chem Supply for our understanding of controlled substance benzodiazepine regulations, comprehensive analytical documentation for triazolobenzodiazepine standards, appropriate packaging for light-sensitive compounds, international regulatory compliance support, and commitment to long-term supply relationships with qualified research organisations.

Can universities and research institutions purchase these products?

Yes, accredited universities and research institutes with appropriate DEA/HC-equivalent licences and institutional review board approvals may procure reference standards for legitimate research purposes. Extensive documentation, end-use certificates, and regulatory compliance verification are required.

How can international businesses request a quotation?

International buyers may request quotations through the realchemsupply.com website contact form, email, or telephone. Please provide product requirements, quantities, shipping destination, institutional credentials, and controlled substance licence information to facilitate accurate pricing and regulatory compliance assessment.

Conclusion

Bromazolam represents a critical reference standard within the triazolobenzodiazepine chemical class, supporting forensic toxicology, clinical laboratory medicine, NPS surveillance, and GABA receptor research across international markets. The bromine substitution and fused triazole structure create distinct analytical and pharmacological characteristics requiring specific differentiation from classical benzodiazepines and other halogenated analogues, making high-quality reference materials essential for reliable identification and research applications.

Real Chem Supply operates as an international B2B chemical supplier dedicated to serving professional laboratories, forensic institutions, clinical facilities, universities, research organisations, and industrial buyers with high-purity benzodiazepine standards and comprehensive analytical documentation. Our global supply infrastructure, regulatory compliance focus, and commitment to professional procurement standards support scientific organisations across Europe, North America, Asia-Pacific, and beyond.

For wholesale enquiries, customised quotations, product specifications, and long-term supply partnerships, qualified laboratories and institutional procurement teams are encouraged to contact realchemsupply.com. Our commercial team provides responsive support for international chemical sourcing, regulatory compliance guidance, and technical consultation regarding benzodiazepine analytics, differentiation protocols, and controlled substance requirements.

Visit https://realchemsupply.com/ to explore our comprehensive catalogue of benzodiazepine reference standards, triazolobenzodiazepine analytical materials, and professional chemical supply solutions.

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