DOC

Professional Substituted Amphetamine Reference Standards for Global Research & Analytical Applications

DOC (4-chloro-2,5-dimethoxyamphetamine, CAS 123431-31-2) is a synthetic substituted amphetamine compound utilised as an analytical reference standard in forensic toxicology, NPS monitoring programmes, and serotonin receptor pharmacology research. As a member of the DOx series of psychedelic phenethylamines, featuring a 4-chloro substitution on the phenyl ring with 2,5-dimethoxy pattern, this compound serves critical functions in laboratories investigating 5-HT₂A receptor interactions, structure-activity relationships, and emerging psychedelic substance identification across Europe, North America, Asia-Pacific, and international professional markets.

At realchemsupply.com, we supply high-purity DOC analytical standards manufactured to stringent industrial specifications for qualified organisations worldwide. Our international B2B chemical supply infrastructure supports forensic laboratories, universities, research institutions, analytical facilities, and industrial manufacturers requiring consistent, documented reference materials for substituted amphetamine differentiation and psychedelic pharmacology research.

---

What Are DOC Products?

Chemical Classification and Overview

DOC belongs to the substituted amphetamine chemical class, specifically the DOx series of psychedelic phenethylamines characterised by methoxy substitutions at the 2- and 5-positions of the phenyl ring. The systematic IUPAC designation is 1-(4-chloro-2,5-dimethoxyphenyl)propan-2-amine, distinguishing it from related DOx compounds by the 4-chloro substitution.

Molecular Formula: C₁₁H₁₆ClNO₂
Molecular Weight: 229.70 g/mol
CAS Registry Number: 123431-31-2
Chemical Class: Substituted amphetamine; DOx psychedelic; Phenethylamine derivative; 5-HT₂A agonist

The 4-chloro-2,5-dimethoxy substitution pattern creates distinct physicochemical properties and receptor binding characteristics compared to other DOx analogues (DOB, DOI, DOM). This structural configuration provides valuable comparative data for structure-activity relationship studies investigating halogen and alkoxy substitution effects on psychedelic pharmacology.

General Characteristics and Industrial Relevance

Substituted amphetamine reference standards like DOC serve essential functions within professional chemical analysis and research workflows:

• Forensic Toxicology: Identification and quantification in biological matrices for post-mortem investigations, clinical toxicology, and impaired driving assessments involving DOx psychedelics
• NPS Surveillance: Early warning system participation and seized material characterisation for border control monitoring DOx series emergence
• Serotonin Receptor Research: 5-HT₂A receptor agonist studies investigating structure-activity relationships and receptor selectivity
• Analytical Method Development: Validation of chromatographic techniques for DOx differentiation from other phenethylamines and amphetamines
• Positional Isomer Studies: Differentiation from related chloro- and methoxy-substituted amphetamines

Professional organisations source these materials through qualified B2B chemical suppliers to ensure batch consistency, documented purity, and regulatory compliance for forensic defensibility.

Procurement Considerations

When sourcing DOC reference standards, professional buyers evaluate:

• Specification Documentation: Comprehensive analytical data including HPLC purity, NMR confirmation, and high-resolution mass spectrometry with chlorine isotope pattern
• Positional Isomer Verification: Capability to distinguish from DOB, DOI, DOM, and other DOx analogues
• Batch Consistency: Reproducible quality across multiple orders for longitudinal forensic studies
• Storage Stability: Light-sensitive compound requiring appropriate packaging
• Regulatory Documentation: Compliance with international substituted amphetamine scheduling and DOx series regulations

Real Chem Supply provides Certificates of Analysis, Safety Data Sheets, and stability data suitable for ISO/IEC 17025 accreditation.

---

Types of Products Available

The DOC category encompasses various product formats suited to professional applications.

Reference Standard Formats

Solid Reference Standards:

• Crystalline powders for precise weighing
• Free-base or salt forms (hydrochloride) depending on stability
• High-purity grades for quantitative analytical applications
• Materials suitable for HRMS, NMR, and chromatographic method development

Prepared Solutions:

• Pre-weighed analytical standards in appropriate solvents
• Concentration-verified solutions for direct instrumental calibration
• Multi-analyte mixtures including related DOx compounds for comparative studies
• Deuterated internal standards for quantitative LC-MS/MS

Analytical Materials:

• HRMS-grade standards for accurate mass confirmation and chlorine isotope verification
• NMR spectroscopy standards for structural confirmation
• Chromatographic standards for retention time library development

Product Form Considerations

Laboratory selection depends upon:

• Application requirements and analytical sensitivity needs
• Stability profiles (hydrochloride salt typically preferred)
• Handling efficiency in high-throughput environments
• Matrix compatibility for intended platforms

Availability varies by batch. Professional buyers should confirm configurations with realchemsupply.com.

---

Industrial and Professional Applications

Forensic Toxicology

• Identification in biological matrices for post-mortem investigations
• Clinical toxicology and overdose assessment involving DOx compounds
• Impaired driving cases involving psychedelic phenethylamines
• Differentiation from DOB, DOI, DOM, and amphetamines

University and Research Applications

• 5-HT₂A receptor binding studies
• Structure-activity relationship research on DOx substitution patterns
• Psychedelic pharmacology and neuropharmacology studies
• Forensic chemistry education and training

Analytical Laboratories

• Confirmation testing following preliminary screening
• Quantitative analysis with isotope dilution methods
• Proficiency testing participation
• Method validation for substituted amphetamine panels

Pharmaceutical Research

• Serotonin receptor drug discovery
• Psychedelic-assisted therapy research (where legally permitted)
• Structure-activity relationship investigations

All applications conducted within professional frameworks with adherence to safety protocols and regulatory requirements.

---

Quality Standards and Procurement Considerations

Product Quality Evaluation

Analytical Documentation:

• HPLC purity determination
• Proton (¹H) and carbon-13 (¹³C) NMR confirmation
• High-resolution mass spectrometry (HRMS) with chlorine isotope pattern
• FT-IR spectral verification

Structural Verification:

• Chromatographic retention time differentiation from DOB, DOI, DOM
• Mass spectrometric fragmentation patterns
• UV-Vis spectroscopic confirmation

Supply Chain Reliability

Evaluation of inventory management, lead times, communication standards, and order fulfilment.

Documentation and Compliance

• Safety Data Sheets (SDS)
• Certificates of Analysis (CoA)
• Regulatory declarations for controlled substance analogues
• Chain of custody documentation

International Logistics

• Customs classification for substituted amphetamines
• Transport regulations compliance
• Import licensing verification
• Documentation accuracy

Buyers should verify applicable regulations before ordering.

---

Product Forms

Solid Forms

Crystalline Materials:

• Defined crystal morphology
• High chemical purity
• Hydrochloride salt for enhanced stability

Amorphous Powders:

• Homogeneous particle size
• Professional packaging with desiccant

Liquid Solutions

• Pre-dissolved analytical standards
• Concentration-verified preparations

Availability depends on specifications. Confirm with realchemsupply.com.

---

Packaging Options

Standard Quantities

• 10 mg – 100 mg: Amber glass vials with desiccant
• 250 mg – 500 mg: Light-protective containers

Features

• Light protection (photosensitive)
• Inert atmosphere where beneficial
• Tamper-evident closures
• GHS-compliant labelling

Bulk quantities may be available upon request.

---

Storage and Handling

Storage Conditions

• Cool, dry environment (2–8°C recommended)
• Protection from light (amber containers)
• Sealed container maintenance

Safety Protocols

• Personal protective equipment
• Fume hood usage
• Spill response procedures
• Controlled substance security where applicable

Documentation

• Batch record maintenance
• Storage condition monitoring

Consult applicable SDS. Comply with local regulations.

---

Why Choose realchemsupply.com?

Professional Sourcing

• Industrial-grade chemical supply
• Comprehensive analytical documentation
• Rigorous batch consistency

International Service

Serving Europe, North America, Asia-Pacific, Middle East, Latin America, and Africa.

Commercial Support

• Bulk availability
• Responsive communication
• Secure professional packaging
• Complete documentation

Long-Term Relationships

• Inventory planning support
• Consistent quality sourcing
• Technical consultation on substituted amphetamine analytics

---

Industries We Supply

Research and Academic

• University chemistry, pharmacology, and forensic science departments
• Research institutes conducting serotonin receptor and psychedelic research

Analytical Laboratories

• Forensic toxicology facilities in Berlin, Paris, Amsterdam, London, New York
• Clinical hospital laboratories
• Commercial testing services

Pharmaceutical Research

• Serotonin receptor drug discovery
• Psychedelic pharmacology research

All customers are qualified professional organisations with appropriate credentials.

---

Global Chemical Supply

Regional Coverage

Europe: Germany, France, Netherlands, Belgium, Spain, Italy, Switzerland, Austria, Scandinavia, UK.

North America: United States, Canada, Mexico.

Asia-Pacific: Japan, South Korea, Singapore, Australia, New Zealand, India.

Other Markets: Brazil, UAE, Saudi Arabia, South Africa.

Logistics and Compliance

International buyers should verify applicable import, export, customs, and transport regulations before ordering.

---

Why International Buyers Choose realchemsupply.com

• Reliable sourcing and supply chain integrity
• Professional B2B procurement experience
• Product availability and inventory
• Professional logistics and packaging
• Long-term supplier relationships

---

Frequently Asked Questions

What is DOC?

DOC (4-chloro-2,5-dimethoxyamphetamine) is a substituted amphetamine compound used as an analytical reference standard for forensic toxicology, NPS monitoring, and serotonin receptor research. It belongs to the DOx series of psychedelic phenethylamines.

Who purchases DOC products?

Professional customers include forensic toxicology laboratories, NPS monitoring programmes, university research departments, and pharmaceutical research organisations. Appropriate credentials required.

Are bulk quantities available?

Bulk quantities may be available depending on specifications and requirements. Contact realchemsupply.com.

Which industries use these chemicals?

Forensic science, clinical toxicology, academic research, and pharmaceutical development. Strictly professional applications.

Can laboratories order wholesale quantities?

Qualified institutions may request commercial pricing. Terms depend on compliance, quantity, and destination.

What packaging is available?

Standard ranges from 10 mg to 500 mg in light-protective amber glass. Custom packaging upon request.

How should DOC products be stored?

Cool, dry conditions (2–8°C), protected from light. Controlled substance security where applicable.

Does realchemsupply.com supply internationally?

Yes, across major markets where regulations permit. Licensing verification required.

Can customised solutions be requested?

Customised packaging and procurement arrangements may be available. Contact commercial team.

Why choose realchemsupply.com?

Professional buyers select us for substituted amphetamine expertise, comprehensive documentation, appropriate packaging, regulatory support, and long-term relationships.

Can universities purchase these products?

Accredited institutions with appropriate licences may procure for legitimate research. Documentation required.

How to request a quotation?

Contact via realchemsupply.com form, email, or telephone with requirements, quantities, destination, and credentials.

---

Conclusion

DOC represents a critical reference standard within the substituted amphetamine and DOx series, supporting forensic toxicology, NPS surveillance, and serotonin receptor research. The 4-chloro-2,5-dimethoxy substitution pattern creates distinct analytical characteristics requiring specific differentiation from related DOx analogues and other phenethylamines.

Real Chem Supply operates as an international B2B chemical supplier serving professional laboratories, forensic institutions, universities, and research organisations with high-purity standards and comprehensive documentation.

For wholesale enquiries, quotations, and supply partnerships, contact realchemsupply.com.

Visit https://realchemsupply.com/ to explore our comprehensive catalogue.