Benzofuran

Professional Benzofuran Scaffold Chemicals for Global Research & Industrial Applications

Benzofuran (coumarone, 2,3-benzofuran, CAS 271-89-6) is a bicyclic heterocyclic aromatic organic compound serving as a fundamental chemical scaffold in pharmaceutical research, agrochemical development, and advanced materials science. As the core structure of numerous biologically active compounds including serotonin receptor ligands and monoamine releasing agents, benzofuran and its derivatives serve critical functions in laboratories investigating structure-activity relationships, novel psychoactive substance identification, and heterocyclic chemistry across Europe, North America, Asia-Pacific, and international professional markets.

At realchemsupply.com, we supply high-purity benzofuran scaffold compounds and derivatives manufactured to stringent industrial specifications for qualified organisations worldwide. Our international B2B chemical supply infrastructure supports pharmaceutical research institutions, forensic laboratories, universities, agrochemical developers, and industrial manufacturers requiring consistent, documented reference materials for benzofuran-based research and development.

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What Are Benzofuran Products?

Chemical Classification and Overview

Benzofuran belongs to the bicyclic heterocycle chemical class, consisting of fused benzene and furan rings. The systematic IUPAC designation is 1-benzofuran or coumarone, reflecting its structure as a furan ring fused to a benzene nucleus at the 2,3-positions.

Molecular Formula: C₈H₆O
Molecular Weight: 118.13 g/mol
CAS Registry Number: 271-89-6
Chemical Class: Bicyclic heterocycle; Aromatic oxygen heterocycle; Pharmaceutical scaffold

Benzofuran serves as the structural scaffold for numerous biologically active compounds, including:

• Aminopropylbenzofurans (APB series): 5-APB, 6-APB, and positional isomers
• Methoxybenzofurans: Substituted derivatives for receptor research
• Halogenated benzofurans: Synthetic intermediates and bioisosteres
• Nitrobenzofurans: Pharmaceutical intermediates

The benzofuran scaffold provides a bioisosteric alternative to indole structures, creating distinct pharmacological profiles while maintaining similar three-dimensional geometry for receptor interactions.

General Characteristics and Industrial Relevance

Benzofuran scaffold chemicals serve essential functions within professional chemical research and industrial applications:

• Pharmaceutical Research: Scaffold for serotonin receptor ligands, particularly 5-HT₂A and 5-HT₂C receptor research
• Forensic Toxicology: Reference standards for benzofuran-derived novel psychoactive substances and positional isomer differentiation
• Agrochemical Development: Intermediate for fungicides, insecticides, and plant growth regulators
• Materials Science: Monomer for polymers and advanced materials with specific electronic properties
• Synthetic Chemistry: Building block for complex heterocyclic synthesis

Professional organisations source these materials through qualified B2B chemical suppliers to ensure batch consistency, documented purity, and regulatory compliance for research and development applications.

Procurement Considerations

When sourcing benzofuran scaffold chemicals and derivatives, professional buyers evaluate:

• Specification Documentation: Comprehensive analytical data including GC purity, NMR confirmation, and HRMS for scaffold integrity
• Isomeric Purity: Verification of positional isomers (5- vs 6-substitution patterns) for forensic applications
• Batch Consistency: Reproducible quality across multiple orders for longitudinal research programmes
• Storage Stability: Light-sensitive aromatic compounds requiring appropriate packaging
• Regulatory Documentation: Compliance with pharmaceutical intermediate and research chemical regulations

Real Chem Supply provides Certificates of Analysis, Safety Data Sheets, and stability data suitable for laboratory accreditation standards including ISO/IEC 17025 requirements.

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Types of Products Available

The benzofuran category encompasses various product formats suited to different professional applications.

Scaffold and Derivative Formats

Parent Benzofuran:

• High-purity scaffold compound for synthetic chemistry
• Reference standard for chromatographic analysis
• Building block for custom synthesis

Substituted Derivatives:

• Aminopropylbenzofurans (5-APB, 6-APB, 5-MAPB, 6-MAPB)
• Methoxybenzofurans for receptor research
• Halogenated intermediates for medicinal chemistry
• Nitro derivatives for synthetic applications

Reference Standards:

• Positional isomer standards (5- vs 6-substitution)
• Deuterated analogues for quantitative analysis
• Metabolite standards where applicable

Product Form Considerations

Laboratory selection depends upon:

• Synthetic requirements versus analytical reference needs
• Scale of operations (milligram to kilogram quantities)
• Purity requirements for pharmaceutical versus forensic applications
• Regulatory considerations for specific derivatives

Availability varies by specific derivative and batch. Professional buyers should confirm configurations with realchemsupply.com.

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Industrial and Professional Applications

Pharmaceutical and Medicinal Chemistry

Pharmaceutical researchers utilise benzofuran scaffolds for:

• Serotonin Receptor Research: 5-HT₂A, 5-HT₂C, and 5-HT₁A receptor ligand development
• Monoamine Transporter Studies: DAT, NET, and SERT interaction research
• Structure-Activity Relationships: Comparison with indole and phenethylamine scaffolds
• Lead Optimisation: Medicinal chemistry programmes targeting CNS indications

Forensic Toxicology and NPS Monitoring

Forensic laboratories employ benzofuran reference standards for:

• Novel Psychoactive Substance Identification: Detection of aminopropylbenzofurans in seized materials
• Positional Isomer Differentiation: Chromatographic separation of 5- vs 6-substituted isomers
• Metabolite Identification: Characterisation of benzofuran metabolic pathways
• Toxicological Casework: Clinical and post-mortem investigations

Agrochemical Development

Industrial researchers utilise benzofuran for:

• Fungicide Synthesis: Benzofuran-derived agricultural fungicides
• Insecticide Development: Intermediate for pest control compounds
• Plant Growth Regulators: Benzofuran-based hormonal analogues

Materials Science and Industrial Chemistry

• Polymer Chemistry: Benzofuran monomers for specialty polymers
• Electronic Materials: Organic semiconductors and conducting polymers
• Fragrance and Flavour: Natural and synthetic benzofuran derivatives

All applications conducted within professional frameworks with adherence to safety protocols and regulatory requirements.

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Quality Standards and Procurement Considerations

Product Quality Evaluation

Analytical Documentation:

• Gas chromatography (GC) purity determination
• Proton (¹H) and carbon-13 (¹³C) NMR spectroscopic confirmation
• High-resolution mass spectrometry (HRMS)
• FT-IR spectral verification

Structural Verification:

• Chromatographic differentiation of positional isomers
• Mass spectrometric fragmentation patterns
• UV-Vis spectroscopic confirmation of aromatic chromophore

Supply Chain Reliability

International chemical procurement requires evaluation of inventory management, lead times, communication standards, and order fulfilment.

Documentation and Compliance

• Safety Data Sheets (SDS)
• Certificates of Analysis (CoA)
• Regulatory declarations for pharmaceutical intermediates
• Chain of custody documentation where required

International Logistics

• Customs classification for heterocyclic compounds
• Transport regulations compliance
• Import licensing verification for controlled derivatives
• Documentation accuracy

Buyers should verify applicable regulations before ordering.

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Product Forms

Solid Forms

Crystalline Materials:

• Defined crystal morphology
• High chemical purity
• Characterised melting point

Amorphous Powders:

• Homogeneous particle size
• Professional packaging

Liquid Solutions

• Pre-dissolved analytical standards
• Concentration-verified preparations

Availability depends on specific derivative. Confirm with realchemsupply.com.

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Packaging Options

Standard Quantities

• 10 g – 100 g: Amber glass containers
• 250 g – 1 kg: Industrial packaging
• Bulk: Commercial quantities upon request

Features

• Light protection
• Inert atmosphere where required
• Moisture control
• GHS-compliant labelling

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Storage and Handling

Storage Conditions

• Cool, dry environment
• Protection from light
• Appropriate ventilation
• Sealed container maintenance

Safety Protocols

• Personal protective equipment
• Fume hood usage for volatile compounds
• Spill response procedures
• Waste management protocols

Consult applicable SDS. Comply with local regulations.

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Why Choose realchemsupply.com?

Professional Sourcing

• Industrial-grade chemical supply
• Comprehensive analytical documentation
• Rigorous batch consistency

International Service

Serving Europe, North America, Asia-Pacific, Middle East, Latin America, and Africa.

Commercial Support

• Bulk availability
• Responsive communication
• Secure professional packaging
• Complete documentation

Long-Term Relationships

• Inventory planning support
• Consistent quality sourcing
• Technical consultation on heterocyclic chemistry

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Industries We Supply

Research and Academic

• University chemistry and pharmacology departments
• Research institutes in Berlin, Paris, Amsterdam, London, New York, Tokyo
• Medicinal chemistry programmes

Pharmaceutical Industry

• Drug discovery and development
• Lead optimisation
• Impurity profiling

Forensic Laboratories

• NPS monitoring and identification
• Toxicology testing
• Seized material analysis

Agrochemical Sector

• Crop protection research
• Plant science applications

All customers are qualified professional organisations with appropriate credentials.

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Global Chemical Supply

Regional Coverage

Europe: Germany, France, Netherlands, Belgium, Spain, Italy, Switzerland, Austria, Scandinavia, United Kingdom.

North America: United States, Canada, Mexico.

Asia-Pacific: Japan, South Korea, Singapore, Australia, New Zealand, India.

Other Markets: Brazil, UAE, Saudi Arabia, South Africa.

Logistics and Compliance

International buyers should verify applicable import, export, customs, and transport regulations before ordering.

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Why International Buyers Choose realchemsupply.com

• Reliable sourcing and supply chain integrity
• Professional B2B procurement experience
• Product availability and inventory management
• Professional logistics and appropriate packaging
• Long-term supplier relationships

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Frequently Asked Questions

What are benzofuran products?

Benzofuran is a bicyclic heterocyclic scaffold used in pharmaceutical research, forensic toxicology, and agrochemical development. It serves as the core structure for numerous biologically active compounds including serotonin receptor ligands.

Who purchases benzofuran products?

Professional customers include pharmaceutical research institutions, forensic laboratories, universities, agrochemical developers, and industrial manufacturers. Appropriate credentials required.

Are bulk quantities available?

Bulk quantities may be available depending on specific derivative and requirements. Contact realchemsupply.com.

Which industries use these chemicals?

Primary industries include pharmaceutical research, forensic science, agrochemical development, and materials science. Applications are strictly professional.

Can laboratories order wholesale quantities?

Qualified institutions may request commercial pricing. Terms depend on compliance, quantity, and destination.

What packaging is available?

Standard ranges from gram to kilogram quantities in appropriate containers. Custom packaging upon request.

How should benzofuran products be stored?

Cool, dry conditions, protected from light, with appropriate ventilation. Consult specific SDS.

Does realchemsupply.com supply internationally?

Yes, across major international markets where regulations permit. Licensing verification may be required for specific derivatives.

Can customised solutions be requested?

Custom synthesis and procurement arrangements may be available. Contact commercial team.

Why choose realchemsupply.com?

Professional buyers select us for heterocyclic scaffold expertise, comprehensive documentation, appropriate packaging, and long-term supply relationships.

Can universities purchase these products?

Accredited institutions with appropriate documentation may procure for legitimate research.

How to request a quotation?

Contact via realchemsupply.com form, email, or telephone with requirements and credentials.

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Conclusion

Benzofuran represents a versatile heterocyclic scaffold supporting pharmaceutical research, forensic toxicology, agrochemical development, and materials science across international markets. The bicyclic structure provides unique pharmacological and physicochemical properties distinct from indole and phenyl scaffolds, making high-quality benzofuran compounds essential for reliable research and development applications.

Real Chem Supply operates as an international B2B chemical supplier serving professional research institutions, forensic laboratories, pharmaceutical developers, and industrial manufacturers with high-purity benzofuran scaffold chemicals and comprehensive analytical documentation.

For wholesale enquiries, customised quotations, and supply partnerships, contact realchemsupply.com.

Visit https://realchemsupply.com/ to explore our comprehensive catalogue.