Clonazolam

Professional Triazolobenzodiazepine Reference Standards for Global Research & Analytical Applications

Clonazolam (6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, also known as clonitrazolam, CAS 33887-02-4) is a synthetic triazolobenzodiazepine compound utilised as an analytical reference standard in forensic toxicology, NPS monitoring programmes, and GABA receptor pharmacology research. As a structurally potent benzodiazepine derivative featuring a fused triazole ring and 2-chlorophenyl substitution, this compound serves critical functions in laboratories investigating high-potency benzodiazepine activity, structure-activity relationships, and emerging substance identification across Europe, North America, Asia-Pacific, and international professional markets.

At realchemsupply.com, we supply high-purity Clonazolam analytical standards manufactured to stringent industrial specifications for qualified organisations worldwide. Our international B2B chemical supply infrastructure supports forensic laboratories, universities, research institutions, analytical facilities, and industrial manufacturers requiring consistent, documented reference materials for benzodiazepine differentiation and potency assessment.

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What Are Clonazolam Products?

Chemical Classification and Overview

Clonazolam belongs to the triazolobenzodiazepine chemical class, characterised by a fused triazole ring incorporated into the 1,4-benzodiazepine scaffold with a 2-chlorophenyl substituent at the 6-position. The systematic IUPAC designation reflects this complex polycyclic structure with chlorine substitution on the phenyl ring.

Molecular Formula: C₁₇H₁₂ClN₅O
Molecular Weight: 337.76 g/mol
CAS Registry Number: 33887-02-4
Chemical Class: Triazolobenzodiazepine; High-potency benzodiazepine derivative

The 2-chlorophenyl substitution, combined with the triazole ring fusion, creates a compound with significantly enhanced potency compared to classical benzodiazepines. This structural configuration distinguishes Clonazolam from clonazepam (nitro-substituted), flubromazolam (fluorine-substituted), and bromazolam (bromine-substituted) analogues in both chemical properties and pharmacological activity.

General Characteristics and Industrial Relevance

Triazolobenzodiazepine reference standards like Clonazolam serve essential functions within professional chemical analysis and research workflows:

• Forensic Toxicology: Identification and quantification in biological matrices for post-mortem investigations, clinical toxicology, impaired driving assessments, and drug-facilitated crime analysis involving high-potency novel benzodiazepines
• NPS Surveillance: Early warning system participation and seized material characterisation for border control and law enforcement monitoring potent emerging benzodiazepines
• GABA Receptor Research: Structure-activity relationship studies investigating potency enhancements through halogenated phenyl substitutions
• Clinical Toxicology: Assessment of overdose potential and withdrawal syndrome characterisation in emergency department presentations
• Analytical Method Development: Validation of ultra-sensitive chromatographic techniques required for low-concentration detection of high-potency compounds

Professional organisations source these materials through qualified B2B chemical suppliers to ensure batch consistency, documented purity, and regulatory compliance for forensic defensibility.

Procurement Considerations

When sourcing Clonazolam reference standards, professional buyers evaluate:

• Specification Documentation: Comprehensive analytical data including HPLC purity, NMR confirmation, HRMS, and verification of structural integrity
• Potency Considerations: Recognition of enhanced pharmacological activity requiring appropriate handling protocols and analytical sensitivity
• Batch Consistency: Reproducible quality for longitudinal forensic studies and research programmes
• Storage Stability: Light-sensitive and hygroscopic compound requiring professional packaging
• Regulatory Documentation: Compliance with international controlled substance scheduling and potent benzodiazepine regulations

Real Chem Supply provides Certificates of Analysis, Safety Data Sheets, and stability data suitable for ISO/IEC 17025 accreditation.

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Types of Products Available

The Clonazolam category encompasses various product formats suited to professional applications.

Reference Standard Formats

Solid Reference Standards:

• Crystalline powders for precise weighing
• High-purity grades for quantitative analytical applications
• Materials suitable for HRMS, NMR, and chromatographic method development

Prepared Solutions:

• Pre-weighed analytical standards in appropriate solvents
• Concentration-verified solutions for direct calibration
• Multi-analyte mixtures for comprehensive screening
• Deuterated internal standards for quantitative LC-MS/MS

Analytical Materials:

• HRMS-grade standards for accurate mass confirmation
• NMR spectroscopy standards for structural verification
• Chromatographic standards for retention time libraries

Product Form Considerations

Laboratory selection depends upon:

• Application requirements and analytical sensitivity needs
• Stability profiles and storage capabilities
• Handling efficiency in high-throughput environments
• Matrix compatibility for intended platforms

Availability varies by batch. Professional buyers should confirm configurations with realchemsupply.com.

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Industrial and Professional Applications

Forensic Toxicology

• Identification in biological matrices
• Post-mortem toxicology investigations
• Impaired driving cases involving novel benzodiazepines
• Drug-facilitated crime analysis

University and Research Applications

• GABA-A receptor binding studies
• Structure-activity relationship research
• Potency comparison studies with classical benzodiazepines
• Forensic chemistry education and training

Clinical Toxicology

• Emergency department overdose assessment
• Withdrawal syndrome characterisation
• Novel benzodiazepine exposure monitoring

Analytical Laboratories

• Confirmation testing following screening
• Ultra-sensitive quantitative analysis
• Method development for low-level detection
• Proficiency testing participation

All applications conducted within professional frameworks with adherence to safety protocols and regulatory requirements.

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Quality Standards and Procurement Considerations

Product Quality Evaluation

Analytical Documentation:

• HPLC purity determination
• NMR spectroscopic confirmation
• HRMS with accurate mass measurement
• FT-IR spectral verification
• Thermal analysis

Structural Verification:

• Chromatographic differentiation from clonazepam, flubromazolam, and related analogues
• Mass spectrometric fragmentation patterns
• UV-Vis spectroscopic confirmation

Supply Chain Reliability

Evaluation of inventory management, lead times, communication standards, and order fulfilment accuracy.

Documentation and Compliance

• Safety Data Sheets (SDS)
• Certificates of Analysis (CoA)
• Regulatory declarations
• Chain of custody documentation

International Logistics

• Customs classification
• Transport regulations compliance
• Import licensing verification
• Documentation accuracy

Buyers should verify applicable regulations before ordering.

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Product Forms

Solid Forms

Crystalline Materials:

• Defined crystal morphology
• High chemical purity
• Characterised melting point

Amorphous Powders:

• Homogeneous particle size
• Professional packaging with desiccant

Liquid Solutions

• Pre-dissolved analytical standards
• Concentration-verified preparations
• Amber glass packaging

Availability depends on specifications. Confirm with realchemsupply.com.

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Packaging Options

Standard Quantities

• 10 mg – 100 mg: Amber glass vials with inert atmosphere
• 250 mg: Light-protective containers

Features

• Light protection
• Inert atmosphere flushing
• Moisture control with desiccant
• Tamper-evident closures
• GHS-compliant labelling

Bulk quantities may be available upon request.

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Storage and Handling

Storage Conditions

• Cool, dry environment (2–8°C)
• Protection from light
• Low humidity with desiccant
• Sealed container maintenance

Safety Protocols

• Personal protective equipment
• Fume hood usage
• Spill response procedures
• Hazardous waste management
• Controlled substance security

Documentation

• Batch record maintenance
• Storage condition monitoring
• Inventory rotation protocols

Consult applicable SDS. Comply with local regulations.

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Why Choose realchemsupply.com?

Professional Sourcing

• Industrial-grade chemical supply
• Comprehensive analytical documentation
• Rigorous batch consistency

International Service

Serving Europe, North America, Asia-Pacific, Middle East, Latin America, and Africa.

Commercial Support

• Bulk availability
• Responsive communication
• Secure professional packaging
• Complete documentation

Long-Term Relationships

• Inventory planning support
• Consistent quality sourcing
• Technical consultation

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Industries We Supply

Research and Academic

• University chemistry and pharmacology departments
• Research institutes conducting NPS and receptor studies

Analytical Laboratories

• Forensic toxicology facilities
• Clinical hospital laboratories
• Commercial testing services

Pharmaceutical Research

• Structure-activity relationship studies
• Method development and validation

All customers are qualified professional organisations with appropriate credentials.

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Global Chemical Supply

Regional Coverage

Europe: Germany, France, Netherlands, Belgium, Spain, Italy, Switzerland, Austria, Scandinavia, United Kingdom.

North America: United States, Canada, Mexico.

Asia-Pacific: Japan, South Korea, Singapore, Australia, New Zealand, India.

Other Markets: Brazil, UAE, Saudi Arabia, South Africa.

Logistics and Compliance

Compliance with import/export regulations, customs documentation, transport safety, and regulatory verification required.

International buyers should verify applicable regulations before ordering.

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Why International Buyers Choose realchemsupply.com

Reliable Sourcing

• Documentation quality for import clearance
• Supply chain security

Professional Procurement

• Quotation responsiveness
• Regulatory guidance
• Efficient processing

Product Availability

• Standard reference standards
• Custom sourcing capabilities

Professional Logistics

• Export packaging compliance
• Documentation accuracy

Long-Term Partnerships

• Account management
• Technical consultation
• Regulatory intelligence

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Frequently Asked Questions

What is Clonazolam?

Clonazolam is a triazolobenzodiazepine compound used as an analytical reference standard for forensic toxicology, NPS monitoring, and GABA receptor research. It is structurally distinct from classical benzodiazepines.

Who purchases Clonazolam products?

Professional customers include forensic laboratories, clinical toxicology facilities, university research departments, and pharmaceutical research organisations. Appropriate credentials required.

Are bulk quantities available?

Bulk quantities may be available depending on specifications and requirements. Contact realchemsupply.com.

Which industries use these chemicals?

Forensic science, clinical toxicology, academic research, pharmaceutical development, and NPS surveillance. Strictly professional applications.

Can laboratories order wholesale quantities?

Qualified institutions may request commercial pricing. Terms depend on compliance, quantity, and destination.

What packaging is available?

Standard ranges from 10 mg to 250 mg in light-protective amber glass. Custom packaging upon request.

How should Clonazolam be stored?

Cool, dry conditions (2–8°C), protected from light, with low humidity. Controlled substance security required.

Does realchemsupply.com supply internationally?

Yes, across Europe, North America, Asia-Pacific, Middle East, Africa, and Latin America where regulations permit. Licensing verification required.

Can customised solutions be requested?

Customised packaging and procurement arrangements may be available. Contact commercial team.

Why choose realchemsupply.com?

Professional buyers select us for benzodiazepine reference standard expertise, comprehensive documentation, appropriate packaging, regulatory support, and long-term relationships.

Can universities purchase these products?

Accredited institutions with appropriate licences may procure for legitimate research. Documentation required.

How to request a quotation?

Contact via realchemsupply.com form, email, or telephone with requirements, quantities, destination, and credentials.

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Conclusion

Clonazolam represents a critical reference standard within the triazolobenzodiazepine class, supporting forensic toxicology, clinical laboratory medicine, NPS surveillance, and GABA receptor research. The 2-chlorophenyl substitution creates distinct analytical and pharmacological characteristics requiring specific differentiation from related analogues.

Real Chem Supply operates as an international B2B chemical supplier serving professional laboratories, forensic institutions, clinical facilities, universities, and research organisations with high-purity benzodiazepine standards and comprehensive documentation.

For wholesale enquiries, quotations, and supply partnerships, contact realchemsupply.com. Our team provides support for international sourcing, regulatory compliance, and benzodiazepine analytics.

Visit https://realchemsupply.com/ to explore our comprehensive catalogue.