Flualprazolam

Professional Triazolobenzodiazepine Reference Standards for Global Research & Analytical Applications

Flualprazolam (6-(2-fluorophenyl)-1-methyl-8-nitro-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, also known as fluo-alprazolam, CAS 28910-91-0) is a synthetic triazolobenzodiazepine compound utilised as an analytical reference standard in forensic toxicology, NPS monitoring programmes, and GABA receptor pharmacology research. As the 2-fluoro analogue of alprazolam, featuring a fluorine substitution on the phenyl ring in place of chlorine, this compound serves critical functions in laboratories investigating halogen structure-activity relationships, metabolic stability comparisons, and emerging high-potency benzodiazepine identification across Europe, North America, Asia-Pacific, and international professional markets.

At realchemsupply.com, we supply high-purity Flualprazolam analytical standards manufactured to stringent industrial specifications for qualified organisations worldwide. Our international B2B chemical supply infrastructure supports forensic laboratories, universities, research institutions, analytical facilities, and industrial manufacturers requiring consistent, documented reference materials for fluorinated benzodiazepine differentiation and structure-activity research.

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What Are Flualprazolam Products?

Chemical Classification and Overview

Flualprazolam belongs to the triazolobenzodiazepine chemical class, characterised by a fused triazole ring incorporated into the 1,4-benzodiazepine scaffold with a 2-fluorophenyl substituent and 8-nitro group. The systematic IUPAC designation reflects this complex polycyclic structure with fluorine and nitro substitutions.

Molecular Formula: C₁₇H₁₂FN₅O₂
Molecular Weight: 353.31 g/mol
CAS Registry Number: 28910-91-0
Chemical Class: Triazolobenzodiazepine; Fluorinated benzodiazepine derivative; Nitrobenzodiazepine analogue

The 2-fluorophenyl substitution, combined with the triazole ring fusion and 8-nitro group, creates a compound with distinct physicochemical properties compared to chlorinated analogues like alprazolam. This fluorinated configuration influences metabolic stability, receptor binding characteristics, and analytical behaviour—factors of significant importance for forensic differentiation and pharmacological research.

General Characteristics and Industrial Relevance

Fluorinated triazolobenzodiazepine reference standards like Flualprazolam serve essential functions within professional chemical analysis and research workflows:

• Forensic Toxicology: Identification and quantification in biological matrices for post-mortem investigations, clinical toxicology, impaired driving assessments, and drug-facilitated crime analysis involving novel fluorinated benzodiazepines
• NPS Surveillance: Early warning system participation and seized material characterisation for border control monitoring fluorinated benzodiazepine emergence
• Halogen SAR Research: Structure-activity relationship studies comparing fluorine versus chlorine substitutions in GABA-A receptor modulation and metabolic stability
• Metabolic Pathway Studies: Investigation of CYP450-mediated metabolism differences between fluoro- and chloro-substituted analogues
• Analytical Method Development: Validation of chromatographic techniques for fluorinated benzodiazepine differentiation from chlorinated and unsubstituted analogues

Professional organisations source these materials through qualified B2B chemical suppliers to ensure batch consistency, documented purity, and regulatory compliance for forensic defensibility.

Procurement Considerations

When sourcing Flualprazolam reference standards, professional buyers evaluate:

• Specification Documentation: Comprehensive analytical data including HPLC purity, NMR confirmation with fluorine signals, and high-resolution mass spectrometry with isotope pattern verification
• Halogen Differentiation: Capability to distinguish from alprazolam (chloro), bromazolam (bromo), and other halogenated triazolobenzodiazepines
• Batch Consistency: Reproducible quality across multiple orders for longitudinal forensic studies and halogen SAR programmes
• Storage Stability: Light-sensitive and potentially hygroscopic compound requiring appropriate packaging
• Regulatory Documentation: Compliance with international fluorinated benzodiazepine scheduling and analogue regulations

Real Chem Supply provides Certificates of Analysis, Safety Data Sheets, and stability data suitable for ISO/IEC 17025 accreditation.

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Types of Products Available

The Flualprazolam category encompasses various product formats suited to different professional applications.

Reference Standard Formats

Solid Reference Standards:

• Crystalline powders for precise weighing and solution preparation
• High-purity grades for quantitative analytical and forensic applications
• Materials suitable for HRMS, NMR (including ¹⁹F NMR), and chromatographic method development

Prepared Solutions:

• Pre-weighed analytical standards in appropriate solvents
• Concentration-verified solutions for direct instrumental calibration
• Multi-analyte mixtures including alprazolam for halogen comparison studies
• Deuterated internal standards for quantitative LC-MS/MS

Analytical Materials:

• HRMS-grade standards for accurate mass confirmation and fluorine isotope pattern verification
• NMR spectroscopy standards including ¹⁹F NMR for fluorine confirmation
• Chromatographic standards for retention time library development

Product Form Considerations

Laboratory selection depends upon:

• Application requirements and analytical sensitivity needs
• Stability profiles and storage capabilities
• Handling efficiency in high-throughput environments
• Matrix compatibility for intended platforms

Availability varies by batch. Professional buyers should confirm configurations with realchemsupply.com.

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Industrial and Professional Applications

Forensic Toxicology

• Identification in biological matrices for post-mortem investigations
• Clinical toxicology and overdose assessment
• Impaired driving cases involving novel fluorinated benzodiazepines
• Drug-facilitated crime analysis

University and Research Applications

• GABA-A receptor binding studies comparing fluoro- versus chloro-analogues
• Structure-activity relationship research on halogen substitutions
• Metabolic stability and CYP450 interaction studies
• Forensic chemistry education and training

Pharmaceutical and Industrial Research

• Bioisostere research comparing fluorine and chlorine substitutions
• Impurity profiling in synthetic process development
• Method validation for fluorinated compound analysis

Analytical Laboratories

• Confirmation testing following preliminary screening
• Quantitative analysis with fluorine-specific detection methods
• Proficiency testing participation

All applications conducted within professional frameworks with adherence to safety protocols and regulatory requirements.

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Quality Standards and Procurement Considerations

Product Quality Evaluation

Analytical Documentation:

• HPLC purity determination
• ¹H, ¹³C, and ¹⁹F NMR spectroscopic confirmation
• HRMS with accurate mass and fluorine isotope pattern
• FT-IR spectral verification

Structural Verification:

• Chromatographic differentiation from alprazolam and halogenated analogues
• Mass spectrometric fragmentation patterns showing fluorine retention
• ¹⁹F NMR confirmation of aromatic fluorine

Supply Chain Reliability

Evaluation of inventory management, lead times, communication standards, and order fulfilment accuracy.

Documentation and Compliance

• Safety Data Sheets (SDS)
• Certificates of Analysis (CoA)
• Regulatory declarations for fluorinated controlled substances
• Chain of custody documentation

International Logistics

• Customs classification for fluorinated heterocyclic compounds
• Transport regulations compliance
• Import licensing verification
• Documentation accuracy

Buyers should verify applicable regulations before ordering.

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Product Forms

Solid Forms

Crystalline Materials:

• Defined crystal morphology
• High chemical purity
• Characterised melting point

Amorphous Powders:

• Homogeneous particle size
• Professional packaging with desiccant

Liquid Solutions

• Pre-dissolved analytical standards
• Concentration-verified preparations
• Amber glass packaging

Availability depends on specifications. Confirm with realchemsupply.com.

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Packaging Options

Standard Quantities

• 10 mg – 100 mg: Amber glass vials with inert atmosphere
• 250 mg – 500 mg: Light-protective containers

Features

• Light protection
• Inert atmosphere flushing
• Moisture control with desiccant
• Tamper-evident closures
• GHS-compliant labelling

Bulk quantities may be available upon request.

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Storage and Handling

Storage Conditions

• Cool, dry environment (2–8°C)
• Protection from light
• Low humidity with desiccant
• Sealed container maintenance

Safety Protocols

• Personal protective equipment
• Fume hood usage
• Spill response procedures
• Hazardous waste management
• Controlled substance security

Documentation

• Batch record maintenance
• Storage condition monitoring
• Inventory rotation protocols

Consult applicable SDS. Comply with local regulations.

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Why Choose realchemsupply.com?

Professional Sourcing

• Industrial-grade chemical supply
• Comprehensive analytical documentation including ¹⁹F NMR where applicable
• Rigorous batch consistency

International Service

Serving Europe, North America, Asia-Pacific, Middle East, Latin America, and Africa.

Commercial Support

• Bulk availability
• Responsive communication
• Secure professional packaging
• Complete documentation

Long-Term Relationships

• Inventory planning support
• Consistent quality sourcing
• Technical consultation on fluorinated benzodiazepine analytics

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Industries We Supply

Research and Academic

• University chemistry, pharmacology, and forensic science departments
• Research institutes conducting halogen SAR and NPS research

Analytical Laboratories

• Forensic toxicology facilities in Berlin, Paris, Amsterdam, London, New York, and international centres
• Clinical hospital laboratories
• Commercial testing services

Pharmaceutical Research

• Fluorinated compound development and bioisostere research
• Method development and validation

All customers are qualified professional organisations with appropriate credentials.

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Global Chemical Supply

Regional Coverage

Europe: Germany, France, Netherlands, Belgium, Spain, Italy, Switzerland, Austria, Scandinavia, United Kingdom.

North America: United States, Canada, Mexico.

Asia-Pacific: Japan, South Korea, Singapore, Australia, New Zealand, India.

Other Markets: Brazil, UAE, Saudi Arabia, South Africa.

Logistics and Compliance

Compliance with import/export regulations, customs documentation, transport safety, and regulatory verification required.

International buyers should verify applicable regulations before ordering.

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Why International Buyers Choose realchemsupply.com

Reliable Sourcing

• Documentation quality for import clearance
• Supply chain security

Professional Procurement

• Quotation responsiveness
• Regulatory guidance
• Efficient processing

Product Availability

• Standard reference standards
• Custom sourcing capabilities

Professional Logistics

• Export packaging compliance
• Documentation accuracy

Long-Term Partnerships

• Account management
• Technical consultation
• Regulatory intelligence

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Frequently Asked Questions

What is Flualprazolam?

Flualprazolam is a fluorinated triazolobenzodiazepine compound used as an analytical reference standard for forensic toxicology, NPS monitoring, and halogen structure-activity research. The 2-fluorophenyl substitution distinguishes it from chlorinated analogues like alprazolam.

Who purchases Flualprazolam products?

Professional customers include forensic laboratories, clinical toxicology facilities, university research departments, and pharmaceutical research organisations. Appropriate credentials required.

Are bulk quantities available?

Bulk quantities may be available depending on specifications and requirements. Contact realchemsupply.com.

Which industries use these chemicals?

Forensic science, clinical toxicology, academic research, pharmaceutical development, and NPS surveillance. Strictly professional applications.

Can laboratories order wholesale quantities?

Qualified institutions may request commercial pricing. Terms depend on compliance, quantity, and destination.

What packaging is available?

Standard ranges from 10 mg to 500 mg in light-protective amber glass. Custom packaging upon request.

How should Flualprazolam be stored?

Cool, dry conditions (2–8°C), protected from light, with low humidity. Controlled substance security required.

Does realchemsupply.com supply internationally?

Yes, across Europe, North America, Asia-Pacific, Middle East, Africa, and Latin America where regulations permit. Licensing verification required.

Can customised solutions be requested?

Customised packaging and procurement arrangements may be available. Contact commercial team.

Why choose realchemsupply.com?

Professional buyers select us for fluorinated benzodiazepine expertise, comprehensive documentation including halogen-specific analytics, appropriate packaging, regulatory support, and long-term relationships.

Can universities purchase these products?

Accredited institutions with appropriate licences may procure for legitimate research. Documentation required.

How to request a quotation?

Contact via realchemsupply.com form, email, or telephone with requirements, quantities, destination, and credentials.

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Conclusion

Flualprazolam represents a critical reference standard within the fluorinated triazolobenzodiazepine class, supporting forensic toxicology, clinical laboratory medicine, NPS surveillance, and halogen structure-activity research. The 2-fluorophenyl substitution creates distinct analytical and pharmacological characteristics requiring specific differentiation from chlorinated analogues, making high-quality reference materials essential for reliable identification and comparative research.

Real Chem Supply operates as an international B2B chemical supplier serving professional laboratories, forensic institutions, clinical facilities, universities, and research organisations with high-purity fluorinated benzodiazepine standards and comprehensive analytical documentation.

For wholesale enquiries, quotations, and supply partnerships, contact realchemsupply.com. Our team provides support for international sourcing, regulatory compliance, and fluorinated benzodiazepine analytics.

Visit https://realchemsupply.com/ to explore our comprehensive catalogue.