HXE

HXE

Professional Arylcyclohexylamine Reference Standards for Global Research & Analytical Applications

HXE (3-hydroxyeticyclidine, also known as 3-HO-PCE, hydroxyeticyclidine, CAS pending) is a synthetic arylcyclohexylamine compound utilised as an analytical reference standard in forensic toxicology, NPS monitoring programmes, and dissociative anaesthetic pharmacology research. As a hydroxylated analogue of eticyclidine (PCE) featuring a 3-hydroxy substitution on the cyclohexyl ring, this compound serves critical functions in laboratories investigating arylcyclohexylamine metabolism, hydroxylated metabolite identification, and dissociative substance structure-activity relationships across Europe, North America, Asia-Pacific, and international professional markets.

At realchemsupply.com, we supply high-purity HXE analytical standards manufactured to stringent industrial specifications for qualified organisations worldwide. Our international B2B chemical supply infrastructure supports forensic laboratories, universities, research institutions, analytical facilities, and industrial manufacturers requiring consistent, documented reference materials for arylcyclohexylamine differentiation and dissociative research applications.

What Are HXE Products?

Chemical Classification and Overview

HXE belongs to the arylcyclohexylamine chemical class, characterised by a cyclohexylamine core with phenyl and hydroxyethyl substitutions. The systematic IUPAC designation is 3-[1-(phenyl)cyclohexyl]oxyethan-1-amine or 3-hydroxy-2-ethylamino-2-phenylcyclohexanone depending on exact structural configuration, reflecting the hydroxylated cyclohexyl ring that distinguishes it from parent eticyclidine and methoxy analogues like MXE.

Molecular Formula: C₁₄H₂₁NO₂
Molecular Weight: 235.32 g/mol
CAS Registry Number: Pending assignment
Chemical Class: Arylcyclohexylamine; Hydroxylated dissociative; NMDA receptor antagonist; Eticyclidine analogue

The 3-hydroxy substitution on the cyclohexyl ring creates distinct physicochemical properties compared to unsubstituted PCE and methoxy analogues like 3-MeO-PCE. This hydroxylated configuration provides valuable comparative data for structure-activity relationship studies investigating hydroxy versus methoxy effects on receptor binding, metabolic stability, and dissociative pharmacology.

General Characteristics and Industrial Relevance

Arylcyclohexylamine reference standards like HXE serve essential functions within professional chemical analysis and research workflows:

  • Forensic Toxicology: Identification and quantification in biological matrices as a potential metabolite of eticyclidine analogues or as a novel dissociative substance
  • NPS Surveillance: Early warning system participation and seized material characterisation for border control monitoring hydroxylated arylcyclohexylamine emergence
  • Metabolite Research: Investigation of 3-hydroxy metabolite formation from parent arylcyclohexylamines via CYP450 hydroxylation
  • NMDA Receptor Pharmacology: Structure-activity relationship studies comparing hydroxy, methoxy, and unsubstituted cyclohexyl analogues
  • Analytical Method Development: Validation of chromatographic techniques for hydroxylated metabolite identification and differentiation

Professional organisations source these materials through qualified B2B chemical suppliers to ensure batch consistency, documented purity, and regulatory compliance for forensic defensibility.

Procurement Considerations

When sourcing HXE reference standards, professional buyers evaluate:

  • Specification Documentation: Comprehensive analytical data including HPLC purity, NMR confirmation with hydroxyl characteristics, and high-resolution mass spectrometry
  • Metabolite Verification: Capability to distinguish from parent PCE, 3-MeO-PCE, MXE, and related arylcyclohexylamine analogues
  • Batch Consistency: Reproducible quality across multiple orders for longitudinal forensic and metabolism studies
  • Storage Stability: Hydroxyl-containing compound requiring appropriate packaging to prevent oxidation
  • Regulatory Documentation: Compliance with international arylcyclohexylamine scheduling and hydroxylated analogue regulations

Real Chem Supply provides Certificates of Analysis, Safety Data Sheets, and stability data suitable for ISO/IEC 17025 accreditation.

Types of Products Available

The HXE category encompasses various product formats suited to professional applications.

Reference Standard Formats

Solid Reference Standards:

  • Crystalline powders for precise weighing
  • Free-base or salt forms (hydrochloride) depending on stability
  • High-purity grades for quantitative analytical applications
  • Materials suitable for HRMS, NMR, and chromatographic method development

Prepared Solutions:

  • Pre-weighed analytical standards in appropriate solvents
  • Concentration-verified solutions for direct instrumental calibration
  • Multi-analyte mixtures including related arylcyclohexylamines for comparative studies
  • Deuterated internal standards for quantitative LC-MS/MS

Analytical Materials:

  • HRMS-grade standards for accurate mass confirmation
  • NMR spectroscopy standards for structural verification
  • Chromatographic standards for retention time library development

Product Form Considerations

Laboratory selection depends upon:

  • Application requirements and analytical sensitivity needs
  • Stability profiles (salt forms typically preferred for hydroxylated compounds)
  • Handling efficiency in high-throughput environments
  • Matrix compatibility for intended platforms

Availability varies by batch. Professional buyers should confirm configurations with realchemsupply.com.

Industrial and Professional Applications

Forensic Toxicology

  • Identification in biological matrices as a metabolite or novel substance
  • Post-mortem toxicology investigations involving arylcyclohexylamines
  • Clinical toxicology and overdose assessment
  • Differentiation from MXE, 3-MeO-PCE, and related dissociatives

University and Research Applications

  • NMDA receptor binding studies on hydroxylated analogues
  • Structure-activity relationship research comparing HO- versus MeO-substitutions
  • Metabolism and CYP450 hydroxylation pathway studies
  • Forensic chemistry education and training

Analytical Laboratories

  • Confirmation testing following preliminary screening
  • Quantitative analysis with isotope dilution methods
  • Proficiency testing participation
  • Method validation for arylcyclohexylamine and metabolite panels

Pharmaceutical Research

  • Dissociative anaesthetic pharmacology
  • Metabolite identification and characterisation
  • Structure-activity relationship investigations

All applications conducted within professional frameworks with adherence to safety protocols and regulatory requirements.

Quality Standards and Procurement Considerations

Product Quality Evaluation

Analytical Documentation:

  • HPLC purity determination
  • Proton (¹H) and carbon-13 (¹³C) NMR confirmation
  • High-resolution mass spectrometry (HRMS)
  • FT-IR spectral verification with hydroxyl band confirmation

Structural Verification:

  • Chromatographic retention time differentiation from 3-MeO-PCE and analogues
  • Mass spectrometric fragmentation patterns (hydroxyl characteristic losses)
  • UV-Vis spectroscopic confirmation

Supply Chain Reliability

Evaluation of inventory management, lead times, communication standards, and order fulfilment.

Documentation and Compliance

  • Safety Data Sheets (SDS)
  • Certificates of Analysis (CoA)
  • Regulatory declarations for arylcyclohexylamine analogues
  • Chain of custody documentation

International Logistics

  • Customs classification for arylcyclohexylamine compounds
  • Transport regulations compliance
  • Import licensing verification
  • Documentation accuracy

Buyers should verify applicable regulations before ordering.

Product Forms

Solid Forms

Crystalline Materials:

  • Defined crystal morphology
  • High chemical purity
  • Hydrochloride salt for enhanced stability

Amorphous Powders:

  • Homogeneous particle size
  • Professional packaging with desiccant

Liquid Solutions

  • Pre-dissolved analytical standards
  • Concentration-verified preparations

Availability depends on specifications. Confirm with realchemsupply.com.

Packaging Options

Standard Quantities

  • 10 mg – 100 mg: Amber glass vials with desiccant
  • 250 mg – 500 mg: Light-protective containers

Features

  • Moisture protection (hydroxyl-containing compound)
  • Inert atmosphere where beneficial
  • Tamper-evident closures
  • GHS-compliant labelling

Bulk quantities may be available upon request.

Storage and Handling

Storage Conditions

  • Cool, dry environment (2–8°C recommended)
  • Protection from moisture and oxidation
  • Sealed container maintenance

Safety Protocols

  • Personal protective equipment
  • Fume hood usage
  • Spill response procedures
  • Controlled substance security where applicable

Documentation

  • Batch record maintenance
  • Storage condition monitoring

Consult applicable SDS. Comply with local regulations.

Why Choose realchemsupply.com?

Professional Sourcing

  • Industrial-grade chemical supply
  • Comprehensive analytical documentation
  • Rigorous batch consistency

International Service

Serving Europe, North America, Asia-Pacific, Middle East, Latin America, and Africa.

Commercial Support

  • Bulk availability
  • Responsive communication
  • Secure professional packaging
  • Complete documentation

Long-Term Relationships

  • Inventory planning support
  • Consistent quality sourcing
  • Technical consultation on arylcyclohexylamine analytics

Industries We Supply

Research and Academic

  • University chemistry, pharmacology, and forensic science departments
  • Research institutes conducting NMDA and dissociative research

Analytical Laboratories

  • Forensic toxicology facilities in Berlin, Paris, Amsterdam, London, New York
  • Clinical hospital laboratories
  • Commercial testing services

Pharmaceutical Research

  • Dissociative anaesthetic pharmacology
  • Metabolite identification research

All customers are qualified professional organisations with appropriate credentials.

Global Chemical Supply

Regional Coverage

Europe: Germany, France, Netherlands, Belgium, Spain, Italy, Switzerland, Austria, Scandinavia, UK.

North America: United States, Canada, Mexico.

Asia-Pacific: Japan, South Korea, Singapore, Australia, New Zealand, India.

Other Markets: Brazil, UAE, Saudi Arabia, South Africa.

Logistics and Compliance

International buyers should verify applicable import, export, customs, and transport regulations before ordering.

Why International Buyers Choose realchemsupply.com

  • Reliable sourcing and supply chain integrity
  • Professional B2B procurement experience
  • Product availability and inventory
  • Professional logistics and packaging
  • Long-term supplier relationships

Frequently Asked Questions

What is HXE?

HXE (3-hydroxyeticyclidine, 3-HO-PCE) is an arylcyclohexylamine compound used as an analytical reference standard for forensic toxicology, NPS monitoring, and NMDA receptor research. The 3-hydroxy substitution distinguishes it from methoxy analogues like MXE.

Who purchases HXE products?

Professional customers include forensic toxicology laboratories, NPS monitoring programmes, university research departments, and pharmaceutical research organisations. Appropriate credentials required.

Are bulk quantities available?

Bulk quantities may be available depending on specifications and requirements. Contact realchemsupply.com.

Which industries use these chemicals?

Forensic science, clinical toxicology, academic research, and pharmaceutical development. Strictly professional applications.

Can laboratories order wholesale quantities?

Qualified institutions may request commercial pricing. Terms depend on compliance, quantity, and destination.

What packaging is available?

Standard ranges from 10 mg to 500 mg in moisture-protective packaging. Custom packaging upon request.

How should HXE products be stored?

Cool, dry conditions (2–8°C), protected from moisture and oxidation. Controlled substance security where applicable.

Does realchemsupply.com supply internationally?

Yes, across major markets where regulations permit. Licensing verification required.

Can customised solutions be requested?

Customised packaging and procurement arrangements may be available. Contact commercial team.

Why choose realchemsupply.com?

Professional buyers select us for arylcyclohexylamine expertise, comprehensive documentation, appropriate packaging, regulatory support, and long-term relationships.

Can universities purchase these products?

Accredited institutions with appropriate licences may procure for legitimate research. Documentation required.

How to request a quotation?

Contact via realchemsupply.com form, email, or telephone with requirements, quantities, destination, and credentials.

Conclusion

HXE represents an important reference standard within the arylcyclohexylamine class, supporting forensic toxicology, NPS surveillance, and NMDA receptor research. The 3-hydroxy substitution creates distinct analytical characteristics as both a potential metabolite and research compound, requiring specific differentiation from methoxy and unsubstituted analogues.

Real Chem Supply operates as an international B2B chemical supplier serving professional laboratories, forensic institutions, universities, and research organisations with high-purity standards and comprehensive documentation.

For wholesale enquiries, quotations, and supply partnerships, contact realchemsupply.com.

Visit https://realchemsupply.com/ to explore our comprehensive catalogue.

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