Bromonordiazepam

Professional Desmethylbenzodiazepine Reference Standards for Global Research & Analytical Applications

Bromonordiazepam (8-bromo-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, also known as desmethylbromazolam, CAS 28911-01-5) is a synthetic benzodiazepine metabolite and analytical reference standard utilised in forensic toxicology, NPS monitoring programmes, and benzodiazepine metabolism research. As the N-desmethyl analogue of bromazolam, this compound serves critical functions in laboratories investigating phase I metabolic pathways, parent-metabolite relationships, and emerging benzodiazepine identification across Europe, North America, Asia-Pacific, and international professional markets.

At realchemsupply.com, we supply high-purity Bromonordiazepam analytical standards manufactured to stringent industrial specifications for qualified organisations worldwide. Our international B2B chemical supply infrastructure supports forensic laboratories, universities, research institutions, analytical facilities, and industrial manufacturers requiring consistent, documented reference materials for benzodiazepine metabolite identification and metabolic pathway studies.

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What Are Bromonordiazepam Products?

Chemical Classification and Overview

Bromonordiazepam belongs to the triazolobenzodiazepine chemical class, specifically representing the N-desmethyl metabolite of bromazolam. The systematic IUPAC designation is 8-bromo-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, reflecting the absence of the N-methyl substituent present in the parent compound. This structural modification creates distinct physicochemical properties and metabolic behaviour compared to bromazolam and other N-alkylated analogues.

Molecular Formula: C₁₆H₁₁BrN₄
Molecular Weight: 339.20 g/mol
CAS Registry Number: 28911-01-5
Chemical Class: Triazolobenzodiazepine; Benzodiazepine metabolite; N-desmethyl analogue

The absence of the 1-methyl group distinguishes Bromonordiazepam from bromazolam, creating differences in lipophilicity, metabolic stability, and receptor binding characteristics. As a primary metabolite of bromazolam, this compound is frequently encountered in forensic toxicological analyses alongside parent compound detection, necessitating reliable reference standards for accurate identification and quantification.

General Characteristics and Industrial Relevance

Benzodiazepine metabolite reference standards like Bromonordiazepam serve essential functions within professional chemical analysis and research workflows:

• Forensic Toxicology: Identification and quantification in biological matrices as a bromazolam metabolite; interpretation of parent-metabolite ratios in post-mortem and clinical cases
• NPS Surveillance: Detection in biological samples from individuals exposed to novel benzodiazepines; monitoring of bromazolam usage patterns through metabolite detection
• Metabolism Research: Investigation of CYP450-mediated N-demethylation pathways; characterisation of phase I metabolic transformations
• Analytical Method Development: Validation of assays capable of simultaneous parent drug and metabolite detection; optimisation of chromatographic separation from bromazolam
• Pharmacokinetic Studies: Determination of metabolic clearance, half-life, and exposure biomarkers for toxicological interpretation

Professional organisations source these materials through qualified B2B chemical suppliers to ensure batch consistency, documented purity, and regulatory compliance for forensic defensibility and research reproducibility.

Procurement Considerations

When sourcing Bromonordiazepam reference standards, professional buyers evaluate:

• Specification Documentation: Comprehensive analytical data including HPLC purity, NMR spectroscopic confirmation, high-resolution mass spectrometry, and differentiation from parent compound
• Metabolite Purity: Confirmation of N-desmethyl structure and absence of N-methylated parent compound contamination
• Batch Consistency: Reproducible quality across multiple orders for longitudinal forensic studies and metabolism research
• Storage Stability: Light-sensitive compound requiring appropriate packaging and handling protocols
• Regulatory Documentation: Compliance with international controlled substance scheduling and metabolite reference material requirements

Real Chem Supply provides Certificates of Analysis, Safety Data Sheets, and stability data suitable for laboratory accreditation standards including ISO/IEC 17025 and forensic quality management systems.

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Types of Products Available

The Bromonordiazepam category encompasses various product formats suited to different professional applications, analytical requirements, and metabolic research needs.

Reference Standard Formats

Solid Reference Standards:

• Crystalline powders for precise weighing and solution preparation
• High-purity grades for quantitative analytical and forensic applications
• Materials suitable for HRMS, NMR, and chromatographic method development
• Metabolite-specific certifications confirming structural identity

Prepared Solutions:

• Pre-weighed analytical standards in appropriate solvents (methanol, acetonitrile, DMSO)
• Concentration-verified solutions for direct instrumental calibration
• Multi-analyte mixtures including bromazolam and Bromonordiazepam for parent-metabolite ratio studies
• Deuterated internal standard preparations for quantitative LC-MS/MS applications

Analytical Materials:

• HRMS-grade standards for accurate mass confirmation and isotopic pattern verification
• NMR spectroscopy standards for structural confirmation
• Chromatographic standards for retention time library development and parent-metabolite separation optimisation

Product Form Considerations

Laboratory selection depends upon:

• Application Requirements: Metabolite identification versus parent-metabolite ratio quantification; forensic casework versus metabolism research
• Stability Profiles: Solid forms offer enhanced stability; solutions require refrigerated storage and light protection
• Handling Efficiency: Pre-prepared solutions reduce variability in high-throughput toxicology laboratories
• Matrix Compatibility: Solvent selection appropriate for biological sample extraction and LC-MS/MS analysis

Availability of specific forms varies by product batch and manufacturing specifications. Professional buyers should confirm current configurations with realchemsupply.com prior to procurement.

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Industrial and Professional Applications

Forensic Toxicology and Metabolite Identification

Forensic laboratories utilise Bromonordiazepam reference standards for:

• Metabolite Confirmation: Identification of bromazolam exposure through detection of primary metabolite in urine, blood, and post-mortem tissues
• Parent-Metabolite Ratio Interpretation: Assessment of metabolic status and timing of exposure in forensic cases
• Confirmation Testing: Definitive identification following preliminary bromazolam screening
• Quantitative Analysis: Calibration curve preparation for metabolite concentration determination

University and Research Institution Applications

Academic research programmes incorporate Bromonordiazepam into:

• Metabolism Studies: Investigation of CYP3A4 and CYP2C19 involvement in N-demethylation; enzyme kinetics and inhibition studies
• Pharmacokinetic Research: Determination of metabolite formation rates, elimination half-life, and exposure biomarkers
• Forensic Chemistry Education: Training in metabolite identification, parent-metabolite relationships, and metabolic pathway interpretation
• Analytical Method Development: Optimisation of assays for simultaneous parent drug and metabolite detection

Clinical Toxicology and Healthcare

Hospital and clinical laboratories employ Bromonordiazepam standards for:

• Overdose Assessment: Detection of bromazolam metabolites in emergency department presentations
• Therapeutic Drug Monitoring: Research applications in benzodiazepine metabolism phenotyping
• Clinical Research: Studies on novel benzodiazepine metabolism in human populations

Pharmaceutical and Industrial Research

Industrial researchers utilise Bromonordiazepam for:

• Impurity Profiling: Identification of N-desmethyl by-products in synthetic processes
• Stability Studies: Assessment of N-demethylation as a degradation pathway
• Method Development: Validation of assays for metabolite quantification in drug development

All applications are conducted within appropriate professional frameworks with adherence to workplace safety protocols, institutional biosafety guidelines, and applicable regulatory requirements.

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Quality Standards and Procurement Considerations

Product Quality Evaluation

Professional procurement teams assess Bromonordiazepam suppliers based on:

Analytical Documentation:

• High-performance liquid chromatography (HPLC) purity determination with UV or MS detection
• Proton (¹H) and carbon-13 (¹³C) NMR spectroscopic confirmation
• High-resolution mass spectrometry (HRMS) with accurate mass measurement (16 Da lower than bromazolam)
• Fourier-transform infrared (FT-IR) spectral verification
• Thermal analysis for solid form characterisation

Structural Verification:

• Chromatographic retention time differentiation from bromazolam (typically shorter due to reduced lipophilicity)
• Mass spectrometric confirmation of N-desmethyl structure (absence of methyl group in fragmentation)
• NMR confirmation of NH proton in triazole ring region

Supply Chain Reliability

International chemical procurement requires evaluation of:

• Inventory Management: Consistent availability for recurring forensic casework and metabolism studies
• Lead Time Transparency: Realistic production schedules
• Communication Standards: Technical support for analytical and regulatory enquiries
• Order Fulfilment: Accurate picking, light-protective packaging, and complete documentation

Documentation and Compliance

Professional buyers require:

• Safety Data Sheets (SDS): Hazard classification, handling precautions, and emergency procedures
• Certificates of Analysis (CoA): Batch-specific analytical results with metabolite identity confirmation
• Regulatory Declarations: Controlled substance status and metabolite reference material classification
• Chain of Custody: Documentation supporting forensic laboratory accreditation

International Logistics Considerations

Cross-border procurement involves:

• Customs Classification: Accurate HS code assignment for heterocyclic compounds
• Transport Regulations: Compliance with dangerous goods requirements
• Import Licensing: Verification of recipient authorisation for scheduled substances
• Documentation Accuracy: Commercial invoices, packing lists, and analytical certificates

Buyers should verify applicable import, export, customs, and transport regulations in their jurisdiction before ordering.

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Product Forms

Bromonordiazepam may be available in various physical forms:

Solid Forms

Crystalline Materials:

• Well-defined crystal morphology
• High chemical purity with characteristic solid-state properties
• Defined melting point for identity confirmation

Amorphous Powders:

• Homogeneous particle size distribution for accurate weighing
• Professional packaging with desiccant and light protection

Liquid and Solution Forms

Prepared Analytical Solutions:

• Pre-dissolved in HPLC-grade or LC-MS-grade solvents
• Concentration-verified by quantitative analytical techniques
• Amber glass packaging with appropriate storage conditions

Availability depends on product specifications and batch characteristics. Professional buyers should confirm current configurations with realchemsupply.com.

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Packaging Options

Real Chem Supply provides professional packaging:

Standard Laboratory Quantities

• 10 mg – 100 mg: Amber borosilicate glass vials with inert atmosphere and desiccant
• 250 mg – 500 mg: Light-protective containers with tamper-evident closures

Commercial and Bulk Options

• Custom packaging: Specialised containers for specific institutional requirements
• Multi-site shipments: Consolidated packaging for distributed laboratory networks

Packaging Features

• Light Protection: Amber glass or aluminium-foil wrapped containers
• Inert Atmosphere: Nitrogen or argon flushing
• Moisture Control: Molecular sieve desiccants
• Tamper Evidence: Sealed closures with integrity indicators
• GHS Labelling: Globally Harmonized System hazard communication

Packaging specifications vary according to requirements. Bulk quantities may be available upon request.

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Storage and Handling

General Professional Storage Guidance

Environmental Conditions:

• Cool, dry storage environment (typically 2–8°C)
• Protection from light and UV exposure
• Low humidity environment with active desiccant

Container Management:

• Maintain sealed closures when not in use
• Minimise headspace exposure during sampling
• Monitor for physical changes indicating degradation

Workplace Safety Protocols

• Personal Protective Equipment: Laboratory coats, safety glasses, and appropriate gloves
• Ventilation: Fume hood usage for powder handling
• Spill Response: Absorbent materials per SDS recommendations
• Waste Management: Institutional hazardous waste protocols
• Security: Controlled substance storage requirements

Documentation and Traceability

• Maintaining batch records and CoA documentation
• Recording opening dates and storage conditions
• Implementing first-in-first-out inventory rotation

Professional users should consult the applicable Safety Data Sheet. Storage protocols must comply with local regulations.

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Why Choose realchemsupply.com?

Professional Chemical Sourcing

• Industrial-grade chemical supply: Materials manufactured to professional specifications
• Reference standard quality: Comprehensive analytical documentation
• Batch consistency: Rigorous quality control

International B2B Service

Serving professional customers across Europe, North America, Asia-Pacific, Middle East, Latin America, and Africa.

Commercial Procurement Support

• Bulk availability: Wholesale quantities for institutions
• Responsive communication: Dedicated support for quotations
• Secure packaging: Professional containers meeting international requirements
• Documentation completeness: CoA, SDS, and regulatory paperwork

Long-Term Supply Relationships

• Inventory planning: Support for recurring requirements
• Consistent quality: Reliable sourcing
• Technical consultation: Guidance on metabolite analytics

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Industries We Supply

Research and Academic Institutions

• Universities: Chemistry, pharmacology, toxicology, and forensic science departments
• Research institutes: Public and private organisations conducting metabolism and NPS research

Analytical and Testing Laboratories

• Forensic laboratories: Police, government, and private toxicology facilities
• Clinical laboratories: Hospital and healthcare system toxicology services
• Commercial testing: Pharmaceutical and industrial analysis services

Pharmaceutical and Industrial Research

• Pharmaceutical manufacturers: Metabolite identification and impurity profiling
• Chemical research: Metabolic pathway studies

All customers are qualified professional organisations with appropriate credentials.

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Global Chemical Supply

International B2B Chemical Procurement

Real Chem Supply facilitates professional chemical procurement across international borders.

Regional Market Coverage

European Markets: Germany (Berlin, Frankfurt, Munich), France (Paris), Netherlands (Amsterdam), Belgium (Brussels), Spain (Madrid), Italy (Milan), Switzerland (Zurich), Austria (Vienna), Scandinavia (Stockholm, Copenhagen), United Kingdom (London).

North American Operations: United States (New York, Los Angeles, Chicago), Canada (Toronto, Vancouver), Mexico (Mexico City).

Asia-Pacific Distribution: Japan (Tokyo), South Korea (Seoul), Singapore, Australia (Sydney, Melbourne), New Zealand (Auckland), India (Mumbai, Delhi).

Other Markets: Brazil (São Paulo), UAE (Dubai), Saudi Arabia (Riyadh), South Africa (Johannesburg).

International Logistics and Compliance

Cross-border supply requires compliance with import/export regulations, customs documentation, transport safety, and regulatory verification.

International buyers should verify applicable regulations before ordering.

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Why International Industrial Buyers Choose realchemsupply.com

Reliable Sourcing and Supply Chain Integrity

• Documentation quality for import clearance
• Supply chain security for controlled substances

Professional B2B Procurement Experience

• Quotation responsiveness
• Regulatory guidance support
• Efficient order processing

Product Availability and Inventory

• Standard metabolite reference standards
• Custom sourcing available

Professional Logistics and Packaging

• Export packaging meeting requirements
• Documentation accuracy
• Chain of custody documentation

Long-Term Supplier Relationships

• Account management
• Technical consultation on metabolite analytics
• Market intelligence on regulatory developments

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Frequently Asked Questions — Global B2B Chemical Procurement

What are Bromonordiazepam products?

Bromonordiazepam (desmethylbromazolam) is the N-desmethyl metabolite of bromazolam, used as an analytical reference standard for forensic toxicology, metabolism research, and NPS monitoring. It serves as a biomarker for bromazolam exposure.

Who purchases Bromonordiazepam products?

Professional customers include forensic toxicology laboratories, clinical laboratories, university research departments, and pharmaceutical manufacturers conducting metabolism studies. All buyers must possess appropriate credentials and authorisations.

Are bulk quantities available?

Bulk quantities may be available depending on specifications, inventory, and requirements. Contact realchemsupply.com to discuss specific needs.

Which industries use these chemicals?

Primary industries include forensic science, clinical toxicology, academic research, pharmaceutical development, and NPS surveillance. Applications are strictly professional and research-oriented.

Can laboratories order wholesale quantities?

Qualified laboratories may request commercial pricing for larger volumes. Terms depend on compliance, quantity, and destination. Contact realchemsupply.com for quotations.

What packaging sizes are available?

Standard packaging ranges from 10 mg to 500 mg in light-protective amber glass. Custom packaging available upon request.

How should Bromonordiazepam products be stored?

Professional storage requires cool, dry conditions (2–8°C), protection from light, and low humidity. Storage must comply with controlled substance security requirements.

Does realchemsupply.com supply international customers?

Yes, we serve professional organisations across Europe, North America, Asia-Pacific, Middle East, Africa, and Latin America where regulatory frameworks permit. Recipient licensing verification required.

Can businesses request customised supply solutions?

Customised packaging and procurement arrangements may be available. Contact our commercial team to discuss needs.

Why choose realchemsupply.com as a chemical supplier?

Professional buyers choose us for metabolite reference standard expertise, comprehensive documentation, appropriate packaging, regulatory compliance support, and long-term supply relationships.

Can universities and research institutions purchase these products?

Yes, accredited institutions with appropriate licences may procure standards for legitimate research. Documentation and compliance verification required.

How can international businesses request a quotation?

Request quotations through realchemsupply.com contact form, email, or telephone. Provide product requirements, quantities, destination, and credentials.

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Conclusion

Bromonordiazepam represents a critical metabolite reference standard within the triazolobenzodiazepine class, supporting forensic toxicology, clinical laboratory medicine, metabolism research, and NPS surveillance. As the primary N-desmethyl metabolite of bromazolam, this compound enables accurate interpretation of parent-metabolite relationships, exposure assessment, and metabolic pathway characterisation.

Real Chem Supply operates as an international B2B chemical supplier dedicated to serving professional laboratories, forensic institutions, clinical facilities, universities, and research organisations with high-purity benzodiazepine metabolite standards. Our global supply infrastructure supports scientific organisations worldwide.

For wholesale enquiries, quotations, and long-term supply partnerships, contact realchemsupply.com. Our commercial team provides support for international sourcing, regulatory compliance, and metabolite analytics.

Visit https://realchemsupply.com/ to explore our comprehensive catalogue of benzodiazepine and metabolite reference standards.